PEPTIDE MANIPULATORS OF REGULATORY T CELL ACTIVITY

摘要

The invention relates to peptide inhibitors of Treg cells. Peptides according to the invention are derived from the FOXP3 protein and inhibit its interaction with NFAT. Such peptides are effective to block the interaction between FOXP3 and NFAT and cause apoptosis in mature regulatory T cells. Such peptides show promising potential for manipulating immune responses in man.