发明名称 |
Human monoclonal antibodies to cell surface and intracellular antigens. |
摘要 |
<p>Human monoclonal antibodies (HmAbs) capable of reacting with cell surface antigens and intracellular components are disclosed. It has been found that HmAbs Ev248, CH5, Chl3, Te39, Hu44, Ge-1, Gr-431, Gr169 and Sp909 may be used to detect these antigens in various cells. By means of these HmAbs malignant cells may be determined. This information may be used to screen metastasized tumors and primary tumors for tissue source and greatly affects the management of these cancers.</p> |
申请公布号 |
EP0163303(A2) |
申请公布日期 |
1985.12.04 |
申请号 |
EP19850106645 |
申请日期 |
1985.05.30 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
COTE, RICHARD J.;THOMSON, TIMOTHY M.;HOUGHTON, ALAN N.;OETTGEN, HERBERT F.;OLD, LLOYD J.;CARDO, CARLOS CORDON |
分类号 |
G01N33/574;A61K39/395;C07K14/005;C07K14/195;C07K16/00;C07K16/30;C07K19/00;C12N5/10;C12N15/02;C12P21/08;C12R1/19;G01N33/567;G01N33/577;(IPC1-7):C12N5/00;C12P21/00 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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