发明名称 N-acyl-2-(cyclo)alkypyrrolidines and piperidines useful as fungicides
摘要 The present invention relates to fungicidal 1-(pyrazolylcarbonyl)piperidines or pyrrolidines, and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
申请公布号 US9357778(B2) 申请公布日期 2016.06.07
申请号 US201314391441 申请日期 2013.04.11
申请人 BAYER CROPSCIENCE AG 发明人 Braun Christoph;Cristau Pierre;Desbordes Philippe
分类号 A01N43/56;C07D403/06;A01N43/06;A01N43/36;A01N43/78 主分类号 A01N43/56
代理机构 Ostrolenk Faber LLP 代理人 Ostrolenk Faber LLP
主权项 1. A compound of formula (I)wherein T represents O or S; n represents 0, 1, 2 or 3; p represents 1 or 2; Q1 represents a direct bond; O; S; SO; or SO2; provided that when n represents 0 then Q1 represents a direct bond; Z1 and Z2 independently represent a hydrogen atom; a halogen atom; cyano; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 5 halogen atoms; substituted or non-substituted C1-C8-alkoxy; substituted or non-substituted C1-C8-alkylsulfanyl; or substituted or non-substituted C1-C8-alkoxycarbonyl; or two substituents Z1 and Z2, together with the carbon atom to which they are linked can form a 3-, 4-, 5- or 6-membered saturated carbocycle that can be substituted by up to four C1-C8-alkyl groups; Z3 represents a hydrogen atom; or substituted or non-substituted C1-C8-alkyl; B represents a substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy-C1-C8-alkyl; substituted or non-substituted C1-C8-alkylsulfanyl-C1-C8-alkyl; substituted or non-substituted C1-C8-alkylsulfinyl-C1-C8-alkyl; substituted or non-substituted C1-C8-alkylsulfonyl-C1-C8-alkyl; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted (C3-C7-cycloalkyl)-C1-C8-alkyl; substituted or non-substituted C4-C7-cycloalkenyl; C4-C7-halogenocycloalkenyl having 1 to 9 halogen atoms; substituted or non-substituted (C4-C7-cycloalkenyl)-C1-C8-alkyl; substituted or non-substituted bicyclo[2.2.1]heptanyl; substituted or non-substituted bicyclo[2.2.1]hept-2-enyl; substituted or non-substituted bicyclo[2.2.2]octanyl; substituted or non-substituted bicyclo[2.2.2]oct-2-enyl; substituted or non-substituted adamantyl; provided that when n represents 0 and Q1 represents a direct bond then B is not methyl or ethyl; R1 and R3 independently represent a halogen atom; nitro; cyano; hydroxy; amino; sulfanyl; pentafluoro-λ6-sulfanyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfinyl; C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfonyl; C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C2-C8-alkenyloxy; substituted or non-substituted C3-C8-alkynyloxy; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; phenoxy; phenylsulfanyl; phenylamino; benzyloxy; benzylsulfanyl; or benzylamino; R2 represents a hydrogen atom; halogen atom; nitro; cyano; hydroxy; amino; sulfanyl; pentafluoro-λ6-sulfanyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfinyl; C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfonyl; C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C2-C8-alkenyloxy; substituted or non-substituted C3-C8-alkynyloxy; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylearbamoyl; phenoxy; phenylsulfanyl; phenylamino; benzyloxy; benzylsulfanyl; or benzylamino;as well as its salts, N-oxides, metal complexes, metalloid complexes and optically active isomers, provided that the following compounds are excluded: [2-(chloromethyl)pyrrolidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone [2-(chloromethyl)piperidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone [2-(3-chloropropyl)pyrrolidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone (3-tert-butyl-1-methyl-1H-pyrazol-4-yl)[2-(2-hydroxyethyl)piperidin-1-yl]methanone (3-tert-butyl-1-isopropyl-1H-pyrazol-4-yl)[2-(2-hydroxyethyl)piperidin-1-yl]methanone (1,3-dimethyl-1H-pyrazol-4-yl)[2-(2-hydroxyethyl)piperidin-1-yl]methanone [2-(2-hydroxyethyl)piperidin-1-yl](1-isopropyl-3-methyl-1H-pyrazol-4-yl)methanone {1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)carbonyl]pyrrolidin-2-yl}acetic acid [2-(hydroxymethyl)pyrrolidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone {2-[(methylamino)methyl]piperidin-1-yl}(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone [2-(2-chloroethyl)piperidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone [(2S)-2-(chloromethyl)pyrrolidin-1-yl][3-(difluoromethyl)-1 -methyl-1H-pyrazol-4-yl]methanone [3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl][(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone [2-(methoxymethyl)piperidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone [2-(2-hydroxyethyl)piperidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone {1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)carbonyl]piperidin-2-yl}acetic acid methyl{1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)carbonyl]piperidin-2-yl}acetate [2-(hydroxymethyl)piperidin-1-yl](1,3,5-trimethyl-1H-pyrazol-4-yl)methanone.
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