| 摘要 |
PURPOSE:To obtain industrially and advantageously the titled compound which is an intermediate for 6,8-substituted-adenosine-3',5'-cyclic phosphates having improved pharmacological action, by reacting adenosine-3',5'-cyclic phosphate (salt) with a specific aldehyde, and reducing the resultant reaction product. CONSTITUTION:Adenosine-3',5'-cyclic phosphate of formula I (A<+> is H<+>, alkali metal ion, ammonium ion or organic ammonium ion) or a salt thereof, e.g. tributylamine salt of adenosine-3',5'-cyclic phosphate, is reacted with an aldehyde of the formula R1CHO (R1 is alkyl, aralkyl or aromatic group), e.g. n-butyraldehyde, in a molar amount of preferably 1-40 times that of the adenosine-3',5'- cyclic phosphate, preferably in a solvent, e.g. acetic acid, to form the corresponding imine compound, which is then reduced with sodium boron hydride, etc. to afford the aimed compound of formula II.
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