Enzyme-inhibitory griseolic acid derivatives, and their use.

摘要

Dihydrodesoxygriseolic acid, which has the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="66" wi="54" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and salts and esters thereof may be prepared by cultivating a suitable strain of Streptomyces, e.g. Streptomyces griseoaurantiacus No. 43894, and, if necessary, salifying or esterifying the free acid. These compounds inhibit the activity of various cyclic nucleotide phosphodiesterases, particularly cAMP PDE, and, as a result of this, have a variety of physiological activities and uses.