Osteoimplant and method of making same

摘要

An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

主权项

1. An osteoimplant which comprises elongate bone particles selected from the group consisting of fully mineralized elongate bone particles, fully demineralized elongate bone particles, substantially fully mineralized elongate bone particles, partially demineralized elongate bone particles, superficially demineralized elongate bone particles, and mixtures thereof wherein mutually contacting elongate bone particles are entangled with each other;
wherein the entangled bone particles form a coherent aggregate matrix, wherein the coherent aggregate matrix possesses an open pore, flexible, sponge-like structure configured to absorb fluids while generally retaining predetermined dimensions; and wherein the osteoimplant comprises a core composed of the fully demineralized elongate bone particles which have not been compacted and an outer surface composed of the superficially demineralized elongate bone particles which have not been compacted surrounding the core.