| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is H, halogen or lower alkyl; R<2> is amino, nitro or acylamino; R<3> is (protected) carboxyl] and its salt. EXAMPLE:1-( 2,3-Dimethylpentanoylamino )-7-methyl-4-oxo-4H-pyrimido[2,1-n]-isoquinoline-3-carboxylic acid. USE:Antiallergic agent. PREPARATION:The compound of formula I (R<3> is protected carboxyl) can be pre pared by reacting the compound of formula II (e.g. 1-amino-4-methyl-7-nitroisoquinoline, etc.) or its salt with the compound of formula III (Ra<3> and Rb<3> are protected carboxyl; R<4> is alkoxy) (e.g. diethyl ethoxymethylenemalonate, etc.).
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