摘要 |
<p>Penem derivs. of formula (I) and their pharmaceutically acceptable salts are new: R = gp.(a); R1 = H or ester gp. hydrolysable in vivo; A = 2-4C alkylene opt. having CH2 replaced by CO, O, S(O)m or NR3; B = CO, CS, CH2 or imino; R2 = H, HCO, alkylcarbonyl, aminocarbonyl or aminosulphonyl (both opt. substd. by N-alkyl), 2-5C alkoxycarbonyl, alkylsulphonyl or alkyl (opt.substd. by CONH2, alkyl-S(O)m, OH, NH2, alkylcarbonylamino, formamido or alkylsulphonylamino, all alkyl 1-4C); R3=H, Me, HCO, MeCO or MeSO2; alk = 1-4C alkylene; n = 0 or 1; m = 0-2.</p> |