QUINOLIZINONE COMPOUND, ITS PREPARATION, AND DRUG COMPOSITION CONTAINING IT

摘要

NEW MATERIAL:A compound shown by the formula I (R<1> is carboxy, amidated carboxy, cyano, etc.; R<7> is H, or aryl; R<2> is H, OH, lower alkyl, etc.; R<3> is H, OH, lower alkyl, lower alkoxy, etc.) and its salt. EXAMPLE:N-[5-( 1H-Tetrazolyl )]-4H-quinolizin-4-one-3-carboxamide. USE:An antiallergic and an antiulcer. PREPARATION:A compound shown by the formula II (R<4> is protected carboxy) or its salt is subjected to eliminated reaction of carboxy-protecting group, to give a compound shown by the formula I a. In the elimination reaction, all the elimination reactions of carboxy-protecting group, such as elimination using hydrolysis, reduction, or Lewis acid, can be applied.