Use of synthetic phosphoglycerides possessing platelet activating properties as desensitizing agents

摘要

Novel synthetic glyceryl-phosphorylcholine compounds are prepared having biological activity paralleling that of naturally generated platelet activating factor. In particular, the novel compounds of the present invention are useful to induce specific desensitization or tachyphylaxis of certain cells and tissues to platelet activating factor, rendering the cells or tissue unresponsive or hyporesponsive to subsequent platelet activating factor stimulation.