NEW 9-HALOGEN-PROSTAGLANDINE

摘要

9-Halogen prostane derivatives of formula I (I), wherein Hal is a chlorine or fluorine atom in the .alpha. or .beta. position, R1 is the radical CH20H or -C-OR2 with R2 is a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R1 is the radical , with R3 is an acid radical or the radical R2 A is a -CH2-CH2-, a trans-CH=CH- or a -C?C- group, W is a free functionally modified hydroxymethylene group or a free or functionally modified group, whereln the OH group may be in the .alpha. or .beta. -position, D and E together form a direct bond or D is a straight-chain, branched-chain or cyclic alkylene group wtth 1 to 10 C-atoms, which may be substituted by fluorine atoms, E represents an oxygen or sulfur atom, a direct bond, a -C?C- bond or a -CR6=CR7-group, where R6 and R7 are different and are a hydrogen atom, a chlorine atom or a C1-C4-alkyl group, R4 a free or functionally modified hydroxy group, and R5 is a hydrogen atom, an alkyl, an alkenyl, a halogen-substituted alkyl, a cycloalkyl, an aryl or a heterocyclic group or when D and E forms a direct bond an alkenyl group and, where R2 is a hydrogen atom, its salts with physiologically tolerable bases useful as pharmaceuticals having compound effects over material prostaglandins.