STEROID MONOHYDRATES, FORMULATIONS CONTAINING SAME AND METHOD

摘要

STEROID MONOHYDRATES, FORMULATIONS CONTAINING SAME AND METHOD The invention provides a monohydrate of a steroid having the structure < IMG > and the 1,2-dehydro derivatives thereof, wherein R1 is chlorine, fluorine or hydroxy and R'1 is hydrogen or R1 and R'1 together are =O; R2 is hydrogen or halogen; R3 is hydrogen, methyl or fluorine; R4 is hydrogen, hydroxy, < IMG > or halogen; and R5 and R6 are the same or different and are hydrogen, alkyl, alkylthio, alkoxy, carboalkoxy, formyl, < IMG > hydroxy, halogen, phenyl or cyano, with the proviso that when R5 and R6 are different, one of R5 and R6 is hydrogen, said monohydrate being in the form of a particulate material having a stable average particle size of less than about 20 microns, a method for forming the monohydrate in said particulate form, and cream and lotion formulations containing the said particulate form steroid monohydrate.