ETHANOLAMINE DERIVATIVE AND INHIBITOR OF BLOOD PLATELET AGGREGATION CONTAINING IT AS ACTIVE INGREDIENT

摘要

NEW MATERIAL:An ethanolamine shown by the formula I (R<1> and R<2> are H, or acyl derived from nicotinic acid, triene higher fatty acid, or pentaenoic acid). EXAMPLE:N-5,8,11,14,17-Eicosapentaenoyl-2-aminoethanol. USE:An inhibitor of blood platelet aggregation. Having strong inhibitory action on blood platelet aggregation, useful as a preventive for thrombosis such as especially myocardial infarction, cerebral infarct, etc. and also as a preventive for cancer metastasis. PREPARATION:For example, nicotinic acid, a triene higher fatty acid, or a pentaene higher fatty acid or its reactive derivative is condensed with ethanolamine in a solvent such as tetrahydrofuran, etc. in an argon atmosphere in the presence of a condensation agent such as ethyl chloroformate, etc. to give a compound shown by the formula I .