| 摘要 |
PURPOSE:To obtain the titled vaccine, by adding aluminum gel and a stabilizer to a purified HBs antigen prepared by a recombinant provided with BHs antigen preparation ability, transformed by recombinant DNA method, lyophilizing the blend. CONSTITUTION:A purified HBs antigen derived from a recombinant, prepared by a recombinant provided with HBs antigen preparation ability, transformed by a recombinant DNA method, is blended with aluminum gel (e.g., aluminum hydroxide gel, aluminum phosphate gel, etc.), a stabilizer (e.g., amino acid such as glycine, saccharide such as glucose, etc.), and, preferably a colloidal agent (e.g., gelatin, etc.), and lyophilized, to obtain lyophilized pharmaceutical preparation of hepatitis B vaccine. It has no reduction in titer, good shelf stability, rapidly dissolving properties and is an extremely improved pharmaceutical preparation. A dose is 5-50mug HBs antigen protein/day, and it is inoculated hypodermically. |
