| 摘要 |
PURPOSE:The titled pharmaceutical preparation wherein clonidine useful as an antihypertensive and a remedy for tonsilitis is provided with stability with time, obtained by blending a drug-containing layer comprising an acrylic polymer as a base material with clonidine or its hydrochloride and citric acid or succinic acid. CONSTITUTION:A drug-containing layer comprising an acrylic polymer having a glass transition temperature of -70--10 deg.C, having pressure-sensitive adhesiveness at normal temperature, is blended with clonidine (chemical name: 2,6-dichloro-N-2-imidazolidinylidenebenzeneamine) and/or its hydrochloride, citric acid and/or succinic acid, and laminated to a substrate material, to give pharmaceutical preparation of drug for endermic administration. Stability of clonidine is improved by addition of citric acid and/or succinic acid, reduction in content can be prevented for a long period, and a sufficient amount of the drug to remedy diseases can administered from the skin to the body. An amount of citric acid, etc. added is preferably 1-4wt% based on the polymer.
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