| 摘要 |
NEW MATERIAL:A compound of formula I [R<1> is OH, OR<4>, SR<4>, SOR<4> (R<4> is 1-3C alkyl); R<2>, R<3> are H, 1-3C alkyl; Ar is pyridyl or phenyl which may be substituted with halogen; X is -C(=O)-, -C(OH)H-; n is 3, 4, 5] and its acid adduct. EXAMPLE:5-{5-[4-( 2-Methoxyphenyl )-1-piperazinyl]valeryl}-2-methoxybenzenesulfoneamide dihydrochloride USE:Hypotensor: it shows satisfactory hypotensive action only with administration of 1-3mg/kg and develops the action promptly with long duration. Further, the low acute toxicity suggests its high safety. PREPARATION:The reaction of an omega-halogenoalkanoylbenzene of formula II(X is halogen) with a piperazine of formula III gives the compound of formula I . |
