MEJORAS EN LA PREPARACION DE CRISTALES GRANDES DEL ACIDO N-BENCILOXICARBONIL-L-ASPARTICO

摘要

N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) crystals several times larger than those obtained by conventional crystallization are prepared by acidifying an alkaline aqueous solution of a metal salt of Z-Asp at high temperatures of between about 20 DEG to 45 DEG C. The resulting large crystals contain less moisture and less impurities such as sodium chloride, dipeptide and benzyl alcohol, etc. than those crystals obtained at lower temperatures and they are easily processed for preparing aspartame.