| 摘要 |
PCT No. PCT/FR82/00181 Sec. 371 Date Jul. 5, 1983 Sec. 102(e) Date Jul. 5, 1983 PCT Filed Nov. 5, 1982 PCT Pub. No. WO83/01619 PCT Pub. Date May 11, 1983.The present invention relates to a process for the preparation of alpha -aspartyl phenylalanine methyl ester by reacting phenylalanine methyl ester with the anhydride of N-formyl L-aspartic acid, process wherein the product from said reaction is treated in at least one ion-exchanging resin column and the beta -isomer contained in the resulting mixture is isomerized by treatment with acetic anhydride followed by an acid hydrolysis to convert said beta -isomer into alpha -isomer and ensure the deformylation of said product. |
