| 摘要 |
Isochromans and oxepines of the formula (I) <IMAGE> in which R<1> denotes a hydrogen atom or a straight or branched alkyl group having up to 4 C atoms, R<2> denotes a hydrogen atom or a straight or branched alkyl group having up to 4 C atoms or, together with R<1>, denotes an alkylene group having 3 to 5 C atoms, R<3> denotes a hydrogen atom or a straight or branched alkyl group having up to 4 C atoms, R<4> denotes a hydrogen atom or a straight or branched alkyl group having up to 4 C atoms, R<5> denotes a hydrogen atom or a straight or branched alkyl group having 1 to 6 C atoms or a pyridinyl group, R<6> denotes a hydrogen atom, a fluorine, chlorine or bromine atom, a straight or branched alkyl group having 1 to 6 C atoms, a hydroxyl or alkoxy group having 1 to 4 C atoms or a trifluoromethyl group, R<7> denotes a hydrogen atom, a fluorine, chlorine or bromine atom, a straight or branched alkyl group having 1 to 6 C atoms, a hydroxyl or alkoxy group having 1 to 4 C atoms or, together with R<6>, denotes a methylenedioxy group, R<8> denotes a hydrogen atom, or a hydroxyl or alkoxy group having 1 to 4 C atoms, m denotes the numbers 1 or 2 and n denotes the numbers 1, 2 or 3, and their acid addition salts. The compounds have calcium antagonist and antihypertensive activity. |
