NOVEL DIASTEREOMER SALTS OF PHENYLALANINE AND N-ACYL DERIVATIVES THEREOF AND PROCESS FOR THE SEPARATION OF OPTICALLY ACTIVE PHENYLALANINE AND N-ACYL DERIVATIVES THEREOF

摘要

The separation of optically active phenylalanine and N-acyl derivatives thereof and novel diastereomer salts of the said compounds. According to the invention a racemic compound of formula (I), is reacted with an optically active resolving agent of formula (II), in a polar solvent and/or a mixture of solvents comprising at least one apolar solvent and optionally an achiral acid or base, thereafter a) when using the D-isomer of the resolving agent of formula (II), the crystalline diastereomer salt formed with the L-isomer of the compound of formula (I) is separated, or b) when using the L-isomer of the resolving agent of formula (II), the crystalline diastereomer salt formed with the D-isomer of the compound of formula (I) is separated, and the enantiomers of the compound of formula (I) from the diastereomer salt or the mother liquor are liberated by the aid of an achiral acid or base and the optically active product is separated in crystalline form.