发明名称 |
Sustained release pharmaceutical compositions |
摘要 |
Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.
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申请公布号 |
US4539199(A) |
申请公布日期 |
1985.09.03 |
申请号 |
US19820384084 |
申请日期 |
1982.06.01 |
申请人 |
EGYT GYOGYSZERVEGYESZETI GYAR |
发明人 |
ORBAN, ERNOE;BORVENDEG, JANOS;NAGY, LASZLO;SOTINEE TOLVAY, MARTA;BANDER, ERZSEBET |
分类号 |
A61K47/48;(IPC1-7):A01N25/12;A61K31/78 |
主分类号 |
A61K47/48 |
代理机构 |
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