发明名称 |
ASYMMETRICAL ALKYL DIPHENYLALKYLAMINOALKYL ESTERS OF 1,4-DIHYDRO-2,6-DIMETHYL-PYRIDINE-3,5-DICARBOXYLIC ACID |
摘要 |
…<CHEM>… Compounds I (Ph = phenyl; Ar = 2 - nitrophenyl, 3-nitrophenyl, 2,3-dichlorphenyl or benzofurazan-4-yl; A = C2 - C6 alkylene; R = C1 - C6 alkyl optionally C1 - C6 alkoxy monosubstituted; R1 = H, OH or C1 - C4 alkyl; R2 = H or CH3) have antihypertensive activity and are effective against coronary heart diseases. They are prepared starting from the aldehyde ArCHO and esters of acetoacetic acid and 3-amino-crotonic acid. Pharmaceutical preparations containing them are also described. |
申请公布号 |
ZA8500656(B) |
申请公布日期 |
1985.08.28 |
申请号 |
ZA19850000656 |
申请日期 |
1985.01.28 |
申请人 |
RECORDATI S.A.;CHEMICAL AND PHARMACEUTICAL COMPANY |
发明人 |
DANTE NARDI;AMEDEO LEONARDI;GABRIELE GRAZIANI;GIORGIO BIANCHI |
分类号 |
A61K31/41;A61K31/435;A61K31/44;A61K31/455;A61P9/08;A61P9/10;A61P9/12;C07C67/00;C07C201/00;C07C205/56;C07D211/90;C07D413/04;C07D413/14 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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