| 摘要 |
PURPOSE:The titled pharmaceutical preparation keeping medicinal effects such as anti-inflammatory action, antirheumatic action, etc., having improved stability of dispersion into a base, improved rectum absorption, having no side effect as it occurs in oral administration, obtained by adding a steroid fatty acid ester to a base for pharmaceutical preparation to be administered to the rectum. CONSTITUTION:A steroid fatty acid ester is added to a base for pharmaceutical preparation to be administered to the rectum, to give the titled pharmaceutical preparation. It is found that a steroid is rapidly absorbed from the rectum, an equivalent nonester type steroid is obtained in a higher blood concentration than oral administration, and its actions when a steroid (e.g., hydrocortisone, prednisolone, etc.) is esterified with a fatty acid ester, preferably 12-20C fatty acid (e.g., myristic acid, palmitic acid, stearic acid, etc). Furthermore, it has no side effects occurring in oral administration and it has improved dispersion stability.
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