摘要 |
NEW MATERIAL:A compound shown by the formula I (R is H, or 1-3C alkyl; n is 0-2). EXAMPLE:4-(2-Thenoyl)-1-piprazinecarboxamide. USE:A remedy and preventive for gastric ulcer and duodenal ulcer. PREPARATION:A piperazine derivative shown by the formula II or its acid addition salt [e.g., 1-(2-thenoyl)piperazine hydrochloride, etc.] is reacted with an alkyl isocyanate shown by the formula R'-NCO (R' is 1-3C alkyl) or an alkali salt of cyanic acid shown by the formula M-OCN (M is Na or K).
|