摘要 |
Compounds of general formula I <IMAGE> (wherein A represents a <IMAGE> group, wherein R7 represents a C1-3 alkyl group, and B represents a methylene or carbonyl group or A represents a -CO-CO- group and B represents a methylene group; E represents an optionally substituted ethylene, n-propylene or n-butylene group; G represents an optionally substituted methylene or ethylene group; R1 and R2 represent a hydroxy, alkyl, alkoxy or phenyl-alkoxy group or one of them represents a hydrogen atom or together they represent an alkylenedioxy group; R3 and R4 represent hydrogen atoms, halogen atoms, trifluoromethyl, hydroxy, alkyl, alkoxy or cyano groups or one of them represents a nitro group or together they represent an alkylenedioxy group; R5 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or optionally substituted amino group; and R6 represents a hydrogen atom, an alkyl, alkenyl, phenylalkyl or acyl group) and acid addition salts thereof show heart-rate reducing activity. <IMAGE> |
申请人 |
DR. KARL THOMAE GMBH |
发明人 |
REIFFEN, MANFRED, DR., DIPL.-CHEM.;HEIDER, JOACHIM, DR., DIPL.-CHEM.;HAUEL, NORBERT, DR., DIPL.-CHEM.;AUSTEL, VOLKHARD, DR., DIPL.-CHEM.;EBERLEIN, WOLFGANG, DR., DIPL.-CHEM.;KOBINGER, WALTER, PROF. DR.;LILLIE, CHRISTIAN, DR.;NOLL, KLAUS, DR., DIPL.-CHEM.;PIEPER, HELMUT, DR., DIPL.-CHEM.;KRUEGER, GERD, DR., DIPL.-CHEM.;KECK, JOHANNES, DR., DIPL.-CHEM. |