TECHNETIUM-99m COMPOSITION FOR LABELLING PROTEINACEOUS MATERIAL AND METHOD

摘要

Chemical compositions for radioactive technetium-99m labelling of proteinaceous material include benzoic acid derivative or a water soluble salt thereof, selected from the group of aminobenzoic, monohydroxy- and dihydroxy-benzoic acid or salt thereof and a stannous salt. The composition may be in the form of a ready-to-use composition of benzoic acid derivative and stannous salt with proteins to be labelled. Ready-to-use compositions with proteins can be prepared in dry form for instant preparation by combination with a radioactive pertechnetate solution. The labelling process is advantageously performed by reduction of pertechnetate by means of divalent tin in a benzoic acid derivative containing solution of the stannous salt. The pH and ionic strength of the solution depends on the proteins or cells which are to be labelled. The compositions are suitable for detection or scintigraphic depiction of processes in human beings or other biological organisms.