摘要 |
<p>A compound having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrognase (PGDH) and having the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="33" wi="81" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which
<UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sub>1</Sub> and R<Sub>2</Sub> are hydrogen or lower alkyl;</ListItem><ListItem>R<Sub>3</Sub> is hydrogen, lower alkyl or substituted or unsubstituted phenyl;</ListItem><ListItem>R<Sub>4</Sub>, R<Sub>5</Sub> and R<Sub>e</Sub> are hydrogen, halogen, lower alkyl, lower alkoxy, cyano, carboxy or nitro; at least one of the groups R<Sub>4</Sub> to R<Sub>6</Sub> being hydrogen;</ListItem><ListItem>R<Sub>7</Sub> to R<Sub>11</Sub> are hydrogen, halogen, cyano, lower alkyl, trifluoromethyl, lower alkoxy, hydroxy, lower acyl, lower alkoxycarbonyl, N,N,-diloweralkyl-aminocarbonyl or N,N-loweralkylene-aminocarbonyl; and R<Sub>8</Sub> to R<Sub>10</Sub> may in addition be carboxy; at least two of R<Sub>7 </Sub>to R<Sub>11</Sub> always being hydrogen; and
-A- is -CO-, -CH<Sub>2</Sub>-CO-, -CH=CH-, -CH=CH-<Sub>CO</Sub>- or corresponding groups in which a hydrogen atom is replaced by a lower alkyl group.</ListItem></UnorderedLists></p><p>The invention comprises also lactones of those compounds in which R<Sub>1</Sub> is hydrogen, and salts of those compounds which contain at least one carboxy group.</p> |