| 摘要 |
NEW MATERIAL:An indane derivative expressed by formula I a or I b (R<2> and R<3> are H, lower alkyl or halogen, provided that R<2> and R<3> in formula I a are not H at the same time) and a salt thereof. EXAMPLE:7-Hydroxy-4-methyl-1-indanone oxime. USE:An antioxidant, having the ability to remove active oxygen species and prevent the formation of lipoperoxides in the living body, and specifically useful as an antiarteriosclerotic agent, carcinogenic preventing agent, carcinostatic agent, anti-inflammatory agent, analgesic agent and remedy for autoimmune diseases, etc. PREPARATION:A compound expressed by formula 2 is reacted with a compound expressed by formula 3 in the presence or absence of a basic compound, e.g. NaOH, in an inert solvent, e.g. methanol or dioxane, to afford the aimed compound expressed by formula I a, which is then catalytically hydrogenated in the presence of a catalyst, e.g. Pd, to give the compound expressed by formula I b.
|
