Hollow glass shell microcarrier for growth of cell cultures, and method of shell manufacture

摘要

A hollow silicate glass microsphere adapted for use as a microcarrier in anchorage-dependent cell cultures, and a process for manufacturing such microspheres. The process of manufacture features a method of tailoring the density of the microspheres to the density of the culture medium by first manufacturing the shells over-dense and then immersing the over-dense shells in an etching solution having the density of the culture medium. As the shells become buoyant, they are removed from the solution.