Antibiotic from Streptomyces clavulicerus

摘要

A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulonic acid has the formula (I): <IMAGE> (I) In addition to being a broad spectrum antibiotic of medium potancy, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of beta lactam antibiotics against many beta -lactamase producing bacteria.