| 摘要 |
<p>Cephalosporin compounds of general formula <CHEM> (wherein Q represents a cyclopropylmethyl goup, Y represents an optionally blocked carboxyl group or an optionally N-mono- or N,N-di-alkyl substituted carbamoyl group, Z represents hydrogen, optionally N-substituted carbamoyloxy, heterocyclicthio or optionally substituted pyridinium or bicyclicpyridinium, R represents an optionally protected amino group, R<2> represents a hydrogen atom or a carboxyl blocking group, B represents -S- or >S->O, and the dotted line indicates DELTA <2> or DELTA <3> unsaturation) and salts thereof. The DELTA <3> sulphide compounds exhibit a particularly advantageous profile of antibiotic activity against both Gram-positive and Gram-negative and organisms, including beta -lactamase-producing strains. Methods of preparing the compounds of the invention are described, as is the use of the compounds as active antibiotics and as precursors therefor.</p> |
