PROCEDE DE PREPARATION DE BENZYL-PHENYL-OSIDES UTILES EN THERAPEUTIQUE

摘要

The present invention relates, by way of new industrial products, to the benzylphenyl osides of the formula (I) in which: X1, X2, X3, X4 and X5, which are identical or different, each represent a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkyl group substituted by one or more halogen atoms (in particular a CF3 group), an OH group, a C1-C4 alkoxy group, a C1-C4 alkoxy group substituted by one or more halogen atoms, a nitro group, a group NR'R'' (in which R' and R'', which are identical or different, each represent the hydrogen atom, a C1-C4 alkyl group or an acetyl group), a methylthio group, a methylsulfinyl group or a mesyl group, and R represents an ose radical chosen from the group comprising (a) the alpha -L-rhamnosyl radical, (b) non-hydrolyzable monosaccharide radicals and (c) non-hydrolyzable monosaccharide radicals in which the hydroxyl group on the carbon atom in the 2-position is replaced with an amine group, the hydroxyl and amine groups of the group R being capable of acetylation, and their addition salts in cases where at least one of the groups X1, X2, X3, X4, X5 and R comprises a basic radical. These new products are useful in therapy. They can be prepared by reducing the corresponding benzoylphenyl and alpha -hydroxybenzylphenyl osides.