TESTOSTERONE-5ALPHA-REDUCTASE INHIBITOR CONTAINING TRITERPENE COMPOUND OR ITS SALT AS ACTIVE INGREDIENT

摘要

PURPOSE:To use testosterone-5alpha-reductase inhibitor comprisng a specific triterpene compound or its salt as a remedy for alopecia, acne, prostatic hypertrophy, etc. without causing side effects like female hormone. CONSTITUTION:The titled inhibitor containing a compound shown by the formula (R1 is OH, OPO3H2, etc; R2 is alpha-, beta -H; R3-4 is CH3, CH2OH, etc.; R5 is alpha-, beta-CH3, etc.; Y is O, or H2; with the proviso that R5 is beta-bond when R2 is in beta-bond), or its salt as an active ingredient. Testosterone-5alpha-reductase has high activity at the target tissue (e.g., gonad, sebaceous gland, prostate, etc.). Then, the titled inhibitor remedies alopecia, acne, prostatic hypertrophy as an anti- male hormone agent. 3beta-Dihydroxy-phosphoryloxy-olean-12-en-18beta-30-oic acid, etc. may be cited as the compound shown by the formula.