MITOGENS OF LEUKOCYTES AND INFLAMED TISSUES AND PROCESS FOR THEIR PREPARATION

摘要

: New mitogens of leukocytes and inflamed tissue are described having the following properties: a) biological activities in vivo and in vitro: selective induction of division and differentiation (mitosis) of bone marrow and/or tissue leukocytes; substantial freedom of other biological effects; b) physico-chemical properties: electrophoretic migration in acrylamide matrices at a pH of 7.40 is anodic; soluble in aqueous media including in 10% ethanol at a pH value of at least 4.0 to 10; adsorb reversibly in structure and biological activity on anion and cation exchangers, calcium phosphate gel and hydroxyapatite and can be subjected in native form to volume partition chromatography. The compounds selectively induce the division and differentiation of leukocytes and their precursors in the bone marrow.