发明名称 |
PREPARATION OF ORTHO-AMINOBENZOTRIFLUORIDE |
摘要 |
This invention relates to a process for the preparation of ortho-aminobenzotrifluoride (OABT) from benzotrifluoride (BTF). The process provides an overall route employing non-isolation of intermediates which can be run smoothly and which results in the preparation of OABT in high yields with less contamination. This process includes a catalytic halogenation step in which BTF is converted to meta-halo BTF and other mono and di-halo isomers of BTF followed by nitration in the same reaction vessel under conditions which do not favor nitration of the di-halo isomers of BTF to produce a mixture which predominates in 5-halo-2-nitro BTF. In the final step the 5-halo-2-nitro BTF present is reduced and hydrodehalogenated with H2 in the presence of a catalyst to form OABT. Recyclable BTF is also obtained from the final reaction. |
申请公布号 |
ZA8407027(B) |
申请公布日期 |
1985.05.29 |
申请号 |
ZA19840007027 |
申请日期 |
1984.09.06 |
申请人 |
MONSANTO COMPANY |
发明人 |
JOHN PAUL CHUPP;THOMAS ELDEN NEUMANN;MICHAEL JEROME MILLER |
分类号 |
C07C17/12;C07C205/12 |
主分类号 |
C07C17/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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