| 摘要 |
PURPOSE:To produce the titled substance useful as a synthetic raw material for an anti-herpes agent, etc., in high yield, by reacting easily available 1-halo-1- perfluoroalkylethylene with water and CO in the presence of an iodine anion generating reagent, a base and a catalyst. CONSTITUTION:The objective compound of formula II can be produced by reacting the 1-halo-1-perfluoroalkylethylene of formula I (X is Cl or Br; Rf is 1-4C perfluoroalkyl) with water and carbon monoxide in the presence of an iodine anion generating reagent, a base such as pyridine and a palladium catalyst under normal or positive pressure at room temperature -150 deg.C. The iodine anion generating reagent is e.g. iodine, tetraethyl ammonium iodide, etc., and its amount is 0.5-10mol% based on the compound of formula I . The amount of the base is preferably 1-5 equivalent. The starting compound of formula I can be synthesized from a perfluoroalkylethylene. |
