| 摘要 |
The present invention relates to compounds of the formula
<CHEM>
wherein n is 0 to 4;
R is hydrogen, an alkali metal or quaternary ammonium cation or a metabolisable ester group;
R1 and R2 are independently hydrogen or lower alkyl;
R4 is hydrogen, lower alkyl or a group of the formula R5CHOH- with R5 being hydrogen, lower alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl;
R6 is amino, loweralkylamino, an alpha -aminoacid residue bonded through the alpha -nitrogen atom or the group -OR8 with R8 being hydrogen, lower alkyl, allyl, aryl, aralkyl, an alkali metal or quaternary ammonium cation or a metabolisable ester group;
R7 is hydrogen, loweralkyl, loweralkoxycarbonyl, aryl, aralkyl, aralkoxycarbonyl, arylsulfonyl, acyl, or, together with the N-hydrogen, the grouping
<CHEM>
wherein either
R9 is aryl and R10 is hydrogen, lower alkyl or aralkyl; or R9 is hydrogen, amino or mono- or dilower-alkylamino and R10 is amino, mono- or diloweralkyl amino, lower alkyl, aryl, aralkyl or lower alkoxycarbonyl; and 1,3-dicarbonyl adducts at the 2 min -amino group when R7 is hydrogen; to pharmaceutical compositions comprising such compounds and methods for preparing them. |
