Pharmacologically active benzo - and dibenzo - pyrones and use.

摘要

Use of compounds of formulae (la) and (lb)
<Chemistry id="chema01" num="0001"><Image id="ia01" he="22" wi="57" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><Chemistry id="chema02" num="0002"><Image id="ia02" he="31" wi="65" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.

In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage iife.

Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (la) or (lb) and optionally mammalian, in particular human, red blood cells.