D-HOMO STEROIDS

摘要

D-Homosteroids of the formula I wherein R4 signifies hydrogen, methyl, chlorine or hydroxy; R6 signifies hydrogen or methylene; R17a.alpha. signifies hydrogen, methyl or chlorine and R17a.beta. signifies carboxy, esterified carboxy, cyano, formyl, carbamoyl, mono(lower alkyl)carbamoyl or di(lower alkyl -carbamoyl; or R17a.alpha. and R17a.beta. together signify a spiroether ring of the formula and wherein the dotted bonds in the D-ring represent an optional 16(17)- or 17(17a)-double bond, have anti-androgenic activity. They can be manufactured in various ways by the molecular transformation of other D-homosteroids.