发明名称 |
ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF 1N-(ALFA-HYDROXY-OMEGA-AMINOALKANOYL)-6'N-METHYL-3',4'-DIDEOXYKANAMYCIN B |
摘要 |
<p>1-N-(alpha-hydroxy-omega-aminoalkanoyl)-6'-N-methyl-3',4'-dideoxyka namycins B or pharmaceutically acceptable acid addition salts thereof are prepared by selective acylation of the 1-amino group of an amino-protected derivative of the formula <IMAGE> in which R1 is a monovalent amino protective group and R2 is hydrogen or a monovalent amino protective group, with an alpha -hydroxyomega -amino acid of the formula V or with a functional derivative thereof, in which n is 1, 2 or 3, R3 is an amino protective group and R4 is hydrogen, or R3 and R4 together are a divalent amino protective group, after which the amino protective groups are eliminated from the 1-N-acylated product obtained in this way. The prepared compounds are effective not only against Gram-negative and Gram-positive bacteria with the usual kanamycin sensitivity but also against kanamycin-resistant bacteria. <IMAGE></p> |
申请公布号 |
DK148262(B) |
申请公布日期 |
1985.05.20 |
申请号 |
DK19750004514 |
申请日期 |
1975.10.07 |
申请人 |
ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI |
发明人 |
HAMAO UMEZAWA;KENJI MAEDA;SHINICHI KONDO;SUMIO UMEZAWA |
分类号 |
C07H15/234;A61K31/70;A61K31/7008;A61K31/7028;A61K31/7034;A61K31/7036;A61P31/04;C07H15/236;(IPC1-7):C07H15/22 |
主分类号 |
C07H15/234 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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