| 摘要 |
<p>1,199,386. N-Aryl anthranilic acid esters. INSTITUTO LUSO FARMACO D'ITALIA S.R.1. 6 Aug., 1968 [12 April, 1968], No. 37461/68. Heading C2C. Novel compounds of formula wherein Y is H, C 1-4 alkyl or acyl, R is H or C 1-4 alkyl and R<SP>1</SP>, R<SP>11</SP> and R<SP>111</SP> are each H, halogen, CF 3 or C 1-4 alkyl, are prepared by one of the following methods: (a) esterification of the N-aryl anthranilic acid with HO-CH(R)-OY, (b) reacting a metal salt of the N-acyl anthranilic acid with Z-CH(R)-OY, where Z is a halogen or tosyl radical, (c) reaction of an acid chloride or anhydride of the N-aryl anthranilic acid with HOCH(R)-OY, (d) ester interchange, (e) reaction of the N-aryl anthranilic acid chloride with an aldehyde and then with the sodium salt of an acid or alcohol, and (f) introduction of Y where it is not H. Pharmaceutical compositions having antiinflammatory antipyretic and analgesic action and in conventional forms for oral, rectal, parenteral and topical administration comprise an above novel compound and a suitable pharmaceutical vehicle.</p> |
