THIOPHENE DERIVATIVE AND PRODUCTION THEREOF

摘要

NEW MATERIAL:A thiophene derivative expressed by formula I (R<1> is H, halogen, 1-3C alkyl or 2-5C acyl; Y is 1-6C alkylene; R<3> and R<4> are H or 1-3C alkyl; m and n are 0 or 1; at least one of m and n is 0). EXAMPLE:3-(2-Thienylmethyl)-2-benzoxazolinone. USE:A medicine capable of exhibiting antiulcer action and medicine for preventing and treating ulcers in the stomach and duodenum of mammals. PREPARATION:A compound expressed by formula II is reacted with a chlorocarbonic acid ester to give a compound expressed by formula III (either one of Z<1> and Z<2> is alkoxycarbonyl; the other is H or alkoxycarbonyl), which is then cyclized under heating to afford the aimed compound expressed by formula I .