| 摘要 |
NEW MATERIAL:A compound shown by the formula I (R' is H, alkyl, alkyl halide, alkoxy, or halogen; R<2> is H, or alkyl; Y is amino, substituted amino, hetero ring, or substituted hetero ring; X is O, or S; n is 0-2). EXAMPLE:5,11-Dihydro-5-[ ( N,N-diisopropylamino)acetyl ] amino[ 1 ]benzoxepino [3,4-b]pyridine. USE:An antitumor agent. PREPARATION:A compound shown by the formula II is reduced, reacted with a halogenating agent, and reacted with ammonia or an amine. The reaction product is further reacted with an acyl halide or an acid anhydride to give a compound shown by the formula III (Q is halogen; m is 1, or 2). The compound is reacted with a compound shown by the formula Y-H, to give a compound shown by the formula I . |
