| 摘要 |
Described is 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol as a mixture of isomers and in its isomeric forms having the structures: <IMAGE> and the uses thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles, and colognes. Also described is a novel process for preparing 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol by first reacting the compound having the structure: <IMAGE> with the compound having the structure: <IMAGE> in order to produce the ketone defined according to the structure: <IMAGE> which is hydrogenated to form the compound having the structure: <IMAGE> and further hydrogenated to form the ketone having the structure: <IMAGE> This ketone is reacted with CH3M wherein M represents Li or MgX and wherein X is chloro, bromo or iodo to form the organometallic intermediate defined according to the structures: <IMAGE> These compounds are then hydrolyzed with dilute acid to form the organoleptically useful 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol isomers of our invention defined according to the structures: <IMAGE>
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