ENANTIOMERT RENA MONOESTRAR AV MALONSYRA OCH ETT ENZYMATISKT FORFARANDE LIKSOM MELLANPRODUKTER FOR FRAMSTELLNING DERAV

摘要

It has the general formula (I), where R1 and R2 independently are hydrogen, hydroxy or lower alkoxy groups with 1-6 carbon atoms esp. methoxy. Diester is hydrolysed in the presence of a hydrolase enzyme. In particular dimethyl enter of malonic acid with the general formula (II), where R1, R2 are as above. The enzymic hydrolysis is carried out in a mixture of solvents which include water and up to 50 vol. % dimethylsulphoxides.