| 摘要 |
NEW MATERIAL:The compound of formula I or formula II (R1 is lower alkylacyl or benzoyl; R2 is benzoic acid residue, 8-21C p-alkylbenzoic acid residue, 6-19C 2-methyl-saturated fatty acid residue, etc.; R3 is benzoic acid residue, 6- 19C 2-methyl-saturated fatty acid residue, 3,4-dimethyl-4-methoxyethoxymethyloxy-2-pentenoic acid residue, etc.). EXAMPLE:15beta-Hydroxyailanthone triacetate-carboxylic acid ester. USE:Antitumor agent. PREPARATION:The compound of formula I can be produced by acylating the 15-OH group of the 15beta-hydroxyailanthone-triacylate of formula III (R1 is acyl) with benzoic acid, 2-methyl-saturated fatty acid, etc. or trans-cinnamic acid, or adding a straight-chain alkyl isocyanate to the 15-OH group, or etherifying the compound. The hydrolysis of the obtained compound of formula I gives the compound of formula II. |
