| 摘要 |
<p>The novel imidazodiazepines of the general formula < IMG > I wherein A together with the two carbon atoms denoted as .alpha. and .beta. signifies a pyridine ring, X signifies an oxygen or sulphur atom, R1 signifies hydrogen, halogen, lower alkyl, lower alkoxymethyl or the group -COOR3 and R2 and R3 each signify lower alkyl, and their pharmaceutically acceptable acid addition salts are useful in the antagonization of the central-depressant, muscle relaxant, ataxic, blood pressure-lowering and respiratory depressant properties of 1,4-benzodiazepines which have tranquillizing activity, for example as antidotes in the case of intoxications with 1,4-benzodiazepines which have tranquillizing activity, for shortening anaesthesia induced by such 1,4-benzodiazepines etc.; they can also be used for suppressing the activity on the central nervous system of 1,4-benzodiazepines which are used in other fields of indication, for example of schistosomicidally-active 1,4-benzodiazepines such as (+)-5-(o-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H- -1,4-benzodiazepin-2-one. The compounds of formula I above can be manufactured according to various methods starting from partly novel starting materials and can be used in galenical administration forms.</p> |
