Pyridine derivs - inhibitors of formation of serum lipids

摘要

(I) R' = H, halogen, or NH2. unsat. alkyl and the group -D-Bh as (1-12C) when B = alkyl, cycloalkyl, phenylalkyl, alkoxyalkyl, aryloxyalkyl, aminoalkyl, l.aminoalkyl, dialkylamino-alkyl, or II (1-5). or, if A = -(CH2)p-O-, B may also be pyranyl, if A = -(CH2)n- -O-, B may also be pyranyl, -(CH2)2N((CH2)2Q), where Q = if A = - -O-, and R' = H, B is not = H, and if A = -CH2- -O-, and R' = H, halogen or NH2, B is not = H. n = 0-3 with R' = H when n = 1, p = 1-4 with R' = H when p = 2, m = 0-4 with m = 0 if B = II(1), II(2), II(3) or II(4), and is bonded to A via N or O. R2 = H, halogen and/or NH2, R3 =, halogen, NH2, or opt. unsatd. alkyl, D = (1-6C) opt. unsatd. alkylene, and -A-B may also be where R4 and R5 = opt. unsatd. alkyl, hydroxyalkyl, or carboxyalkyl. II Acid addn. salts of I. Hypolipaemics and vasodilators. 1-nicotinoyl-3,5-dimethylpyrazole (4.2g.). m.p. 43-4 deg.