摘要 |
<p>3-(2-(4-(4-fluorobenzoyl) 1-piperidinyl)ethyl) 2,4-(1H,3H) quinazoline-dione is made by (a) reacting 2-amino N-(2-(4-(4-fluorobenzoyl) 1-piperidinyl)ethyl) benzamine with 1,1'-bis (1H-imidazol-1-yl) methanone in inert solvent such as dichloromethane, chloroform or other at 60-80 deg.C, to obtain 3-(2-(4-(4-fluorobenzoyl) 1-piperidinyl)ethyl)2,4(1H,3H)quinazoline-d ione; isolating the prod. by conventional methods; and (c) recrystallising from N,N-dimethyl formamide to obtain the pure prod..</p> |