| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I [R<1> is H, or (protected) OH; R<2> and R<3> are (protected)OH; R<4> is (protected)aldehyde]. EXAMPLE:2',4'-Di-O-acetyl-3-O-t-butyldimethylsilyl-23-deoxy-23-oxo mycaminosyl tylonolide diethyl acetal shown by the formula II. USE:An antibacterial agent, and an intermediate for preparing mycaminosyl tylonolide. PREPARATION:A compound shown by the formula III (R<5> is protected OH; R<6> is protected aldehyde; with the proviso that R<5> and R<6> are the same group as that of protected OH and aldehyde) is reacted with pyridinium-trifluoroacetate and N,N-dicylohexyl carbodiimide usually in a mixed solvent of anhydrous dimethyl sulfoxide and anhydrous benzene at room temperature, and the protecting group is eliminated.</p> |
